                        Changes in version 0.1.4                        

  - extract_instruments() and check_phenotypes() now harmonise with
    TwoSampleMR action = 1, assuming all alleles are on the forward
    strand as they are in OpenGWAS. Previously the default action = 2
    inferred the strand of palindromic SNPs from their allele
    frequencies, which differ between populations, so palindromic SNPs
    whose allele frequencies were on different sides of 0.5 in the
    reference population had their beta and eaf wrongly flipped, and
    palindromic SNPs with intermediate allele frequencies were dropped.
    extract_instruments() gains a harmonise_strictness argument.
  - Fix the FDR adjustment in
    estimate_instrument_heterogeneity_per_variant() and
    mrgxe_plot_variant(). It was applied separately to each SNP, so Qfdr
    equalled Qpval and the default SNP selections in mrgxe() and
    mrgxe_plot_variant() used unadjusted p-values. mrgxe() now returns
    an ungrouped tibble.
  - Bump the required version of ieugwasr

                        Changes in version 0.1.3                        

  - Fix CAMERA_local so it can be initialised and run: add the missing
    radius field, store ld_ref, call the class's own methods, fix the
    exposure/outcome subsetting, stop mc.cores being passed as pthresh,
    use mc.cores (default 1, so it works on Windows) in all parallel
    calls, use the minmaf setting when reading files, and declare its
    dependencies (data.table, GenomicRanges, IRanges, parallel) in
    Suggests (thanks @Mercy-Kimani)

                        Changes in version 0.1.2                        

  - Additional amends to the tutorial
      - Show loading of the example data and state when it was created
      - Explain how to install genetics.binaRies or supply a plink
        executable
      - Remove the unused x$clone() and clarify how make_outcome_data()
        and harmonise() update the object
      - Add an overview of the CAMERA methods with links to their
        documentation
  - Regenerate the example data used in the tutorial from OpenGWAS,
    using an ieugwasr version which corrects the signs of the beta and
    eaf of the ukb-e datasets returned by associations(), and update the
    tutorial text to match the new results
  - Fix swapping of the effect and other alleles in
    extract_instrument_regions() when a dataset's effect allele differs
    from the first dataset's
  - Expand the documentation of the instrument_heterogeneity(),
    estimate_instrument_specificity() and cross_estimate() methods,
    including their output columns and the null hypotheses of their
    p-values

                        Changes in version 0.1.1                        

  - Various fixes to documentation and vignettes

                        Changes in version 0.1.0                        

  - First release of package
